Clinical Metagenomics

How next-generation sequencing — from foundational technology to clinical practice — is reshaping infectious disease diagnostics.

About this series

What you'll learn

Clinical metagenomics is the use of high-throughput sequencing to read all of the DNA in a clinical sample, identify every organism present, and characterize the genes those organisms carry — including resistance markers. It's the closest thing modern microbiology has to a universal diagnostic.

This series covers high-stakes clinical applications in infectious disease, microbiome research reshaping our understanding of human health, and the AI tools beginning to interpret sequencing data at scale.

If you're a clinician, lab director, biopharma partner, or researcher trying to understand where infectious disease diagnostics are headed, start here.

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Articles in this series

Svante Pääbo Receives Nobel Prize for DNA Sequencing Technology

Ancient-DNA sequencing won the 2022 Nobel — and the same techniques are reshaping clinical metagenomics today.

Clinical Metagenomics

Next-Generation Sequencing for UTI Diagnosis

What NGS is, how it differs from culture and PCR, and why it matters for difficult UTI cases.

Diagnosing UTIs

Sepsis Awareness: The Current Global Health Crisis and What We Can Do About It

Sepsis kills 11 million people each year. Faster, broader pathogen ID could change the outcome.

Clinical Metagenomics

AI in Genomics: Using BIOTIA-DX Resistance to Decode Antimicrobial Resistance

How AI-powered tools are transforming the way we detect and interpret resistance genes from microbial genomes.

Industry News

The Tripledemic: Why Viruses Are Hitting Harder This Year and What Can Be Done

RSV, influenza, and COVID-19 are colliding — straining hospitals and accelerating antimicrobial resistance.

Industry News

Mining the Microbes That Affect Our Behavior Using Next-Generation Sequencing

The gut–brain axis is real — and metagenomics is revealing how the microbiome shapes mood and behavior.

Microbiome Science

Running with Trillions of Microbes: The Microbiome of a Marathoner

Endurance training reshapes the gut microbiome — and certain microbes may even enhance performance.

Microbiome Science

Exploring Novel Therapeutics for C. difficile Awareness Month

Why C. difficile recurs so often — and how microbiome-restoring therapies are changing the playbook.

Microbiome Science

Why Did My Urine Culture Come Back Negative?

Standard culture misses up to 1 in 3 UTIs. Here's why — and what you can do about it.

Diagnosing UTIs

Hitchhiker Resistance Genes in International Travelers

Travel reshapes your gut resistome. Metagenomic studies show how antibiotic resistance crosses borders.

Research and Evidence

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